Current Issue : July-September Volume : 2022 Issue Number : 3 Articles : 1 Articles
The current investigation aims to develop nano ethosomes for transdermal delivery of rasagiline mesylate. The nano ethosomes were prepared by the cold method, varying the variables such as phospholipids, ethanol and propylene glycol concentrations. At the same time, entrapment efficiency, particle size and transdermal permeability of a gel were the chosen responses. Results indicate that the nano ethosomes of rasagiline mesylate provides lesser particle size, better entrapment efficiency and improved transdermal delivery of a gel as compared to rigid liposomes. The optimized formulation rasagiline mesylate nano ethosomes obtained was further evaluated for an in-vitro diffusion activity. Optimized nano ethosomal formulation with the particle size of 106.2 nm showed 91.11% entrapment efficiency and in-vitro drug release of 90.56%. Nano ethosomes proved significantly superior regarding the amount of drug permeated into the skin. In-vitro diffusion study of carbopol 934 loaded nano ethosomal gel showed significant higher percent inhibition of diffusion membrane compared with oral administration of rasagiline mesylate. Our results suggest that nano ethosomes are an efficient carrier for transdermal delivery drug of rasagiline mesylate....
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